I found that Word and Excel were s l o w to start after I upgraded to SL. Safari was a tad slow as well.
After validating fonts and disabling dupes, I ran the beta version of Onyx for SL and ran maintenance scripts and cleaned font cache.
Amazing. Everything is much faster now. It took Safari a moment to rebuild, but after closing and reopening, it was lightning fast.
Wish I could say the same of Office, but at least it is as fast as it ever was, which means anything Office is still the slowest app on my Mac. At least now it’s opening under twenty seconds again instead of almost a full minute.
Thought I’d pass this along in case it is helpful to anyone else or in case you have another suggestion for post-SL install maintenance.