You can quit an app that is running, without bringing it to the front or switching to that Mission Control desktop. Use Command+Tab to bring up the application switcher. Continue to hold down the Command key and Tab through the list to the app you wish to quit. Then, while still holding Command, press Q to quit the app. You can continue to hold down the Command key and use Tab and Q to quit other apps. Use Shift+Tab to move backwards through the list.
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