If you'd rather not take your hands off the keyboard to access the Mac menu bar, you can execute any menu command using a keyboard shortcut. You can then use the arrow keys to navigate through the menu items and Return to select one. You can do something similar with the Dock as well.
If you use Command+Shift+g to get around in the Finder, you don’t need to type every letter of a folder name. After a few characters, you can press the Tab key to autocomplete it. So if you type ~/Doc and then press Tab, you will most likely get ~/Documents/.
When you have a Safari window open with multiple tabs, using Command+w will close the current tab. If you want to do the opposite and close all of the other tabs and leave the current one open, use Command+Option+W.
In Sierra you can rearrange almost all menubar icons by holding down the Command key and dragging them left or right. But the ones you need most on the right so you don’t lose them when you are running an app that has a large set of menus on the left.















